Tottenham must wait for swelling to go down on Harry Kane’s injured ankle before assessing the full extent of the problem.
The England striker suffered the blow in the dying moments of Sunday’s 1-0 defeat to Manchester United and will be scanned once the injury has settled down.
It is the third successive season that he has sustained an ankle injury, the most recent one keeping him out for a fortnight last March.
Kane was injured after being caught in the middle of Phil Jones and Victor Lindelof as Spurs chased an equaliser against United.
He received treatment after the full-time whistle before walking off the Wembley pitch extremely gingerly.
Kane did not emerge through the mixed zone after full-time as he was selected for a post-match doping test, so it was unclear how heavily he was walking or whether he had a foot brace on or needed crutches.
Any lengthy absence for Kane would leave Spurs short of attacking options ahead of an important part of the season, with Son Heung-min away on international duty, Lucas Moura still injured himself and Fernando Llorente and Vincent Janssen expected to leave the club this month.
Defender Jan Vertonghen is backing his team-mates to cover the potential absence of Kane and Son.
“We have to assess the other cases as well but these two guys are just massive for us,” he said.
“Especially over the last couple of months, they’ve been immense. We’ve got other great players.
“They’re also vital for us but we hope they’ll both be back soon.”
